ESPN has fired head coach Gary Kubiak and fired general manager Trent Baalke.
They have named Kevin C. Cox as interim head coach and Andy Licht as the new head coach.
The move comes after a year in which the organization went through a significant restructuring.
ESPN has a history of coaching changes at the network.
Former general manager Mike Sherman was fired in September 2016.
In the interim, they have fired several assistants.
This marks the first time the network has fired a head coach since the merger with NBC in 1998.
Kubiak was a three-year NFL head coach for the Raiders, Chargers, Raiders and Ravens.
He had a 6-13 record with a 5-11 record in two seasons as head coach of the Browns.
In a statement, ESPN said Cox and Licht would remain on the staff until the search for the next coach is complete.
Cox is a veteran of three NFL head coaching jobs and the first African-American head coach in the NFL.
He spent his entire playing career with the Baltimore Ravens.
Licht, a former NFL defensive coordinator, spent eight seasons with the Raiders and Oakland Raiders.
He played for the Chargers, Cowboys and Redskins.
The 49ers, Colts and Seahawks have been rumored as potential candidates.
The Broncos, Falcons and Raiders are the only teams that have hired coaches since the NFL merged in 2000.
The Bengals and Redskins are the teams with the least history of hiring coaches.
The Texans hired former Broncos and Texans coach Romeo Crennel as head football coach in May 2016.
Crennell has been in Houston since 2012.
He was fired by the Broncos after the 2016 season.